The Construction of Analogy-Based Research Programs

The Lock-and-Key Analogy in 20th Century Biochemistry

When the German chemist Emil Fischer presented his lock-and-key hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity.

Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling.

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2019-03-12, 224 pages
ISBN: 978-3-8376-4442-5

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Rebecca Mertens

Rebecca Mertens, Universität Bielefeld, Deutschland

Author(s)
Rebecca Mertens
Book title
The Construction of Analogy-Based Research Programs The Lock-and-Key Analogy in 20th Century Biochemistry
Publisher
transcript Verlag
Pages
224
Features
kart., Klebebindung, 12 SW-Abbildungen
ISBN
978-3-8376-4442-5
DOI
Commodity Group
1510
BIC-Code
PDX PDA PDR
BISAC-Code
SCI034000 PHI004000 SCI075000
THEMA-Code
PDX PDA PDR
Release date
2019-03-12
Edition
1
Topics
Medizin, Wissenschaft
Readership
Science Studies, History, Philosophy, Biochemistry, Molecular Biology, Immunology, Sociology, Literary Studies
Keywords/Tags
Lock-key Hypothesis, Analogy, Research Program, Molecular Biology, Biochemistry, History of Science, Science, Medicine, Philosophy of Science, Sociology of Science, Life Sciences, History

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